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Semin Cancer Biol. 2002 Apr;12(2):131-8.

Regulation of membrane type-matrix metalloproteinases.

Author information

1
Department of Pathology, Wayne State University, Detroit, MI 48201, USA.

Abstract

Pericellular proteolysis is a hallmark of tumor cell metastasis. The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a distinctive group of membrane-bound MMPs that are central mediators of surface proteolytic events that regulate tumor cell motility, metastasis and angiogenesis. As membrane-tethered proteases, the MT-MMPs exhibit unique regulatory mechanisms and interactions with metalloproteinase inhibitors and other relevant molecules. This review will focus on new emerging information on the mechanisms that regulate MT-MMP processing, activity and inhibition, and their significance for enzyme function in the tumor microenvironment.

PMID:
12027585
DOI:
10.1006/scbi.2001.0421
[Indexed for MEDLINE]

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