BSE: a consequence of cattle feeding with glycated molecules host-unknown?

Med Hypotheses. 2002 Apr;58(4):276-8. doi: 10.1054/mehy.2001.1519.

Abstract

Although there is much evidence supporting a prion contribution in the pathogenesis of transmissible spongiform encephalopathies, a novel point of view as to the induction of the diseases can be proposed. It is hypothesized that neurodegenerative diseases, such as scrapie in sheep and goats and bovine spongiform encephalopathy in cattle (BSE), originate from the consumption of glycated proteins contained in their feed. These components are obtained during a high-temperature glycation process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed / adverse effects*
  • Animal Feed / analysis
  • Animals
  • Cattle
  • Dietary Proteins / adverse effects*
  • Dietary Proteins / pharmacokinetics
  • Encephalopathy, Bovine Spongiform / etiology*
  • Glycation End Products, Advanced / adverse effects*
  • Glycation End Products, Advanced / pharmacokinetics
  • Glycoproteins / adverse effects*
  • Glycoproteins / pharmacokinetics
  • Maillard Reaction
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / metabolism
  • Rumen / metabolism

Substances

  • Dietary Proteins
  • Glycation End Products, Advanced
  • Glycoproteins
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic