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Eksp Klin Farmakol. 2002 Jan-Feb;65(1):77-80.

[Anti-arrhythmic properties of GABA and GABA-ergic system activators].

[Article in Russian]

Author information

Pharmacology and Biopharmacy Chair, Department of Postgraduate Medical Training, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia.


Clinical and experimental data available in the literature are summarized, which are indicative of the antiarrhythmogenic properties of GABA and substances possessing GABA-positive activity (phenibut, piracetam, sodium hydroxybutyrate, lithium hydroxybutyrate, etc.). The antiarrhythmic effects are manifested in various cases of the heart rhythm violation. The mechanism of this action is related to activation of the central and peripheral retarding GABAergic system, as well as to antihypoxant, antioxidant, and antistressor effects.

[Indexed for MEDLINE]

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