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Emerg Infect Dis. 2002 Jun;8(6):625-30.

Parachlamydiaceae: potential emerging pathogens.

Author information

1
Unité des Rickettsies, Université de la Méditerranée, Marseille, France.

Abstract

Parachlamydiaceae, which naturally infect amoebae, form a sister taxon to the Chlamydiaceae on the basis of the Chlamydia-like cycle of replication and 80% to 90% homology of ribosomal RNA genes. Because intra-amoebal growth could increase the virulence of some intracellular bacteria, Parachlamydiaceae may be pathogenic. Arguments supporting a pathogenic role are that Chlamydia pneumoniae, a well-recognized agent of pneumonia, was shown to infect free-living amoebae and that another member of the Chlamydiales, Simkania negevensis, which has 88% homology with Parachlamydia acanthamoebae, has caused pneumonia in adults and acute bronchiolitis in infants. The recent identification of a 16S rRNA gene sequence of a Parachlamydiaceae from bronchoalveolar lavage is additional evidence supporting potential for pathogenicity.

PMID:
12023921
PMCID:
PMC2738484
DOI:
10.3201/eid0806.010210
[Indexed for MEDLINE]
Free PMC Article

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