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J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):691-700.

Presenile dementia syndromes: an update on taxonomy and diagnosis.

Author information

1
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.

Abstract

The four major degenerative dementias that often begin in presenescence: are reviewed. These are Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and Creutzfeldt-Jakob disease. Their epidemiological, genetic, and clinical features are reviewed, and controversies in taxonomy arising from recent discoveries described. Particular attention is given to the pathological role of protein aggregation, which appears to be a factor in each disease.

PMID:
12023408
PMCID:
PMC1737933
[Indexed for MEDLINE]
Free PMC Article

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