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J Biol Chem. 2002 Aug 16;277(33):30091-101. Epub 2002 May 21.

Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration.

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Research Center for Genetic Medicine, Children's National Medical Center, and Genetics Program, George Washington University, Washington, D. C. 20010, USA.


Temporal expression profiling was utilized to define transcriptional regulatory pathways in vivo in a mouse muscle regeneration model. Potential downstream targets of MyoD were identified by temporal expression, promoter data base mining, and gel shift assays; Slug and calpain 6 were identified as novel MyoD targets. Slug, a member of the snail/slug family of zinc finger transcriptional repressors critical for mesoderm/ectoderm development, was further shown to be a downstream target by using promoter/reporter constructs and demonstration of defective muscle regeneration in Slug null mice.

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