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FEBS Lett. 2002 May 22;519(1-3):169-72.

Human septin-septin interaction: CDCrel-1 partners with KIAA0202.

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1
Children's Hospital, University of Freiburg, Mathildenstr. 1, Freiburg, Germany.

Abstract

Septins are evolutionary conserved cytoskeletal GTPases forming heteropolymer complexes involved in cytokinesis and other cellular processes. CDCrel-1 (cell division cycle related-1) is a recently cloned and characterized human septin which is highly expressed in non-dividing cells, such as neurons. Using a yeast two-hybrid system we demonstrate that CDCrel-1 partners with another uncharacterized human septin, KIAA0202. The interaction of CDCrel-1 and KIAA0202 was confirmed in the human leukemia cell line K-562 using pull-down assays with a KIAA0202-glutathione S-transferase fusion protein and by immunoprecipitation of the CDCrel-1-KIAA0202 complex with an anti-KIAA0202 antibody. Expression studies of the two human septins revealed a concomitant expression of both proteins in certain cells.

PMID:
12023038
DOI:
10.1016/s0014-5793(02)02749-7
[Indexed for MEDLINE]
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