Osteogenesis distraction and platelet-rich plasma for bone restoration of the severely atrophic mandible: preliminary results

J Oral Maxillofac Surg. 2002 Jun;60(6):630-5. doi: 10.1053/joms.2002.33107.

Abstract

Purpose: The purpose of this study was to evaluate a new method of restoring severe atrophic mandible using platelet-rich plasma (PRP) during distraction osteogenesis.

Materials and methods: Since 1999, 2 men and 3 women with severe atrophy (Cawood and Howell classes V and VI) of a completely edentulous mandible have been treated with a novel distraction procedure. During the surgery, a mixture of autologous bone graft, harvested from the iliac crest, and an autologous platelet concentrate, obtained from platelet-rich plasma, filled the distraction gap. This mixture constituted an autologous bone-platelet gel that was used to create a useful bony scaffold for distraction regenerate. After a latency period of 15 days, a distraction run of 0.5 mm/d, and a 60-day period of consolidation, the distraction device was removed and implants were placed simultaneously.

Results: In all treated patients, planned distraction height was achieved with a considerable enhancement of bony regeneration, and in all cases it was possible to place implants at a planned time.

Conclusions: The combination of these recent and innovative regenerative methods seems to be effective in restoring the severe atrophic mandible.

Publication types

  • Clinical Trial

MeSH terms

  • Alveolar Bone Loss / surgery*
  • Alveolar Ridge Augmentation / methods*
  • Bone Regeneration
  • Bone Transplantation
  • Dental Implantation, Endosseous
  • Female
  • Gels
  • Humans
  • Jaw, Edentulous / surgery
  • Male
  • Mandible / surgery*
  • Mandibular Diseases / surgery
  • Middle Aged
  • Osteogenesis, Distraction / methods*
  • Platelet Transfusion*

Substances

  • Gels