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Virchows Arch. 2002 May;440(5):543-6. Epub 2002 Jan 22.

Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung.

Author information

1
Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G. Ripamonti 435, 20141 Milan, Italy. giuseppe.pelosi@ieo.it

Abstract

Meningothelioid nodules (MNs) are not uncommon lesions of the pulmonary interstitium composed of monomorphic round to spindle cells, likely reactive in nature. Their origin is unsettled, though a derivation from arachnoid-like cells in conditions of perturbed perfusion of the pulmonary tissue has been proposed. Here we confirm the consistent occurrence of intense progesterone-receptor immunoreactivity in MNs fortuitously detected in surgical specimens of lung carcinomas. This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth.

PMID:
12021930
DOI:
10.1007/s00428-001-0580-y
[Indexed for MEDLINE]

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