Format

Send to

Choose Destination
Biochim Biophys Acta. 2002 Jun 21;1602(2):151-61.

Polycomb repression: from cellular memory to cellular proliferation and cancer.

Author information

1
Department of Molecular Genetics, The Netherlands Cancer Institute, H5, Plesmanlaan 121, Amsterdam, The Netherlands.

Abstract

The transcriptional repressors of the Polycomb group (PcG), together with the counteracting Trithorax group (TrxG) proteins, establish a form of cellular memory by regulating gene expression in a heritable fashion at the level of chromatin. This cellular memory function is required for a correct cell fate/behavior, which is not only crucial during development for the generation of a correct body plan but also later in life to prevent cellular transformation. Here, we summarize the rapidly accumulating data that implicate several mammalian PcG members in the control of cellular proliferation and tumorigenesis.

PMID:
12020801
DOI:
10.1016/s0304-419x(02)00052-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center