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Dev Cell. 2002 May;2(5):677-83.

In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis.

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1
Abteilung Zellbiologie, Biozentrum der Universit├Ąt Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

Abstract

In the developing tracheal system of Drosophila melanogaster, six major branches arise by guided cell migration from a sac-like structure. The chemoattractant Branchless/FGF (Bnl) appears to guide cell migration and is essential for the formation of all tracheal branches, while Decapentaplegic (Dpp) signaling is strictly required for the formation of a subset of branches, the dorsal and ventral branches. Using in vivo confocal video microscopy, we find that the two signaling systems affect different cellular functions required for branching morphogenesis. Bnl/FGF signaling affects the formation of dynamic filopodia, possibly controlling cytoskeletal activity and motility as such, and Dpp controls cellular functions allowing branch morphogenesis and outgrowth.

PMID:
12015974
[Indexed for MEDLINE]
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