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Dev Cell. 2002 May;2(5):518-9.

Cyclin G: a regulator of the p53-Mdm2 network.

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Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.


A recent study published in the April issue of Molecular Cell has shown that cyclin G, a p53 target, is a regulatory component of the active PP2A holoenzyme, which activates Mdm2 through dephosphorylation. These findings suggest that cyclin G is a key regulator of the p53-Mdm2 network.

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