Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2002 Jun 1;34(11):E54-8. Epub 2002 May 7.

Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection.

Author information

1
Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador-Bahia, Brazil.

Abstract

The epidemiologic and immunologic findings for 104 subjects with subclinical Leishmania braziliensis infection were compared with those for 29 patients with cutaneous leishmaniasis (CL) from the same area of endemicity. Subjects had a positive leishmania skin test result and remained asymptomatic during the next 4 years of follow-up were considered to have subclinical infection. Patients with CL were younger, had larger-diameter indurations after skin testing, and were more likely to have positive serologic markers than were those with subclinical infection (P<.05). In subjects with subclinical infection, levels of interferon-gamma and tumor necrosis factor-alpha in lymphocyte supernatants were lower than they were in patients with CL (P<.05); however, mean interleukin-5 levels were slightly higher in patients with subclinical infection than in patients with CL. These data indicate that, unlike patients with CL, individuals who do not develop disease when infected with L. braziliensis may have the ability to modulate their immune response.

PMID:
12015707
DOI:
10.1086/340261
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center