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Exp Anim. 2002 Apr;51(2):167-71.

Circling mouse, a spontaneous mutant in the inner ear.

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Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College, Seoul 137-701, Korea.


A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

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