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Neuro Endocrinol Lett. 2002 Apr;23(2):109-13.

Bright light therapy and/or imipramine for inpatients with recurrent non-seasonal depression.

Author information

1
Psychiatric centre Prague, 3rd Medical Faculty Charles University Prague, Czech Republic. prasko@pcp.lf3.cuni.cz

Abstract

INTRODUCTION:

The aim of a double-blind study was to assess the efficacy of bright light therapy and/or imipramine in the treatment of inpatients suffering with recurrent non-seasonal major depressive disorder.

METHOD:

34 in-patients with DSM-III-R diagnosis of major depressive disorder, recurrent type, were randomly allocated into 3 treatment groups. After 4-day washout period with baseline assessment they underwent 3 weeks of different types of treatment: a) Group A: bright light therapy (5000 lux from 6-8 a.m.) and imipramine 150 mg/day. b) Group B: bright light therapy (5000 lux from 6-8 a.m.) and imipramine-like placebo. c) Group C: dim red light (500 lux from 6-8 a.m.) and imipramine 150 mg/day. Outcome measures included weekly Hamilton Psychiatric Rating Scale for Depression, Clinical Global Impression Scale, Montgomery and Asberg Psychiatric Rating Scale for Depression and Beck Depression Inventory.

RESULTS:

Patients of all three groups improved significantly. The improvement of the patients of group B treated with bright light therapy plus placebo was superior to the other two groups, but not significantly.

CONCLUSION:

Bright light therapy can be effective in the treatment of non-seasonal major depressive disorder.

PMID:
12011795
[Indexed for MEDLINE]
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