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Neurology. 2002 May 14;58(9):1404-7.

Safety, tolerability, and efficacy of orally administered cannabinoids in MS.

Author information

1
Department of Neurology, VU Medical Center, Amsterdam, the Netherlands. J.Killestein@vumc.nl

Abstract

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.

PMID:
12011290
DOI:
10.1212/wnl.58.9.1404
[Indexed for MEDLINE]

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