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J Am Chem Soc. 2002 May 22;124(20):5638-9.

Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene.

Author information

1
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.

Abstract

Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield.

PMID:
12010027
DOI:
10.1021/ja026007t
[Indexed for MEDLINE]

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