Format

Send to

Choose Destination
See comment in PubMed Commons below
Metab Eng. 2002 Apr;4(2):114-23.

The mathematics of metabolic control analysis revisited.

Author information

1
Kluyverlaboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands.

Abstract

In this minireview, several different approaches to derivation of the theorems and relationships of Metabolic Control Analysis (MCA) are discussed and an alternative approach is presented. This new approach consists of solving the steady-state mass balances for the intracellular metabolites using linearized kinetics. The application of linearized kinetics reflects the fact that MCA is based on linearization of the system equations in a reference steady state. Our derivation is valid for metabolic networks of arbitrary complexity, including those containing conserved moieties and branches. The value of our approach is its simplicity: the derivation is straightforward and therefore easy to follow. It can serve as a compact introduction to the mathematical basis of MCA.

PMID:
12009791
DOI:
10.1006/mben.2001.0216
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center