Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cardiovasc Med. 2002 Apr;12(3):108-14.

VEGF gene delivery for treatment of ischemic cardiovascular disease.

Author information

1
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305-5175, USA.

Abstract

There are increasing numbers of patients with ischemic myocardial disease not amenable to traditional methods of revascularization. These patients may benefit from new research into the use of naturally occurring angiogenic compounds, such as vascular endothelial growth factor (VEGF) for re-establishing blood flow into regions of hibernating myocardium. Animal studies and human clinical trials evaluating VEGF demonstrate increases in myocardial perfusion after treatment, with some patients reporting improvement in anginal symptoms. Further research into the ideal form of VEGF therapy (protein, plasmid, or adenoviral) and delivery method (intracoronary, intramyocardial, or epicardial) seems justified.

PMID:
12007735
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center