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Curr Biol. 2002 Apr 30;12(9):R316-8.

Mitosis: aurora gives chromosomes a healthy stretch.

Author information

1
Department of Molecular and Cell Biology, Harvard University, 16 Divinity Ave, Room 3000, Cambridge, MA 02138, USA. bstern@mcb.harvard.edu

Abstract

Attachment of sister chromatids to microtubules from opposite spindle poles--bi-orientation--generates tension at the kinetochores. The Ipl1/Aurora B kinase responds to the absence of tension at mono-oriented chromosomes and promotes microtubule turnover and spindle checkpoint activation until a stable bi-oriented attachment is achieved.

PMID:
12007431
DOI:
10.1016/s0960-9822(02)00828-x
[Indexed for MEDLINE]
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