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[Interaction between HTLV-1 transcription activator tax and Taxreb107].

[Article in Chinese]

Author information

1
Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China.

Abstract

Tax is a transcription activator encoded by human T-cell leukemia virus (HTLV)-1. Ribosomal protein L6 was also defined as Taxreb107 (Tax responsible element binding protein 107) for its activity of binding to the long terminal repeats of HTLV-1. To investigate the relationship between Tax and Taxreb107/RpL6, yeast two hybrid and GST pull-down assays were used. Results suggest that Tax can interact with Taxreb107/RpL6 directly and Taxreb107/RpL6 may regulate the function of Tax in HTLV-1 proliferation.

PMID:
12007002
[Indexed for MEDLINE]
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