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Headache. 2002 Feb;42(2):114-9.

Oral magnesium load test in patients with migraine.

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1
Department of Neurology, Medical Faculty, University of Pécs, Hungary.

Abstract

OBJECTIVE:

To determine whether migraineurs may have a systemic deficiency of magnesium.

BACKGROUND:

Magnesium deficiency has been shown to play a potential role in the pathogenesis of migraine, but there are no data on total body magnesium status in migraineurs.

METHODS:

An oral magnesium load test was performed by giving 3000 mg of magnesium lactate during a 24-hour interictal period to 20 patients with migraine (15 women and 5 men; mean age, 37.9 years) and 20 healthy volunteers (16 women and 4 men; mean age, 39.6 years). Baseline and postload magnesium concentrations were determined from serum and 24-hour urine specimens.

RESULTS:

There was no significant difference between the groups in the baseline serum and urine magnesium concentrations, although the latter tended to be lower (P = .064) in the migraine group. The postload magnesium concentrations were significantly higher within both the migraine (P < .0001 and P < .0001) and the control (P = .0009 and P < .0001) groups compared to the baseline values. After loading, the 24-hour urinary magnesium excretions were significantly lower (P = .0007) in the patients with migraine than in the controls, but serum values did not differ.

CONCLUSIONS:

Magnesium retention occurs in patients with migraine after oral loading, suggesting a systemic magnesium deficiency.

PMID:
12005285
[Indexed for MEDLINE]
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