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Nat Rev Immunol. 2002 Apr;2(4):283-91.

The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?

Author information

1
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. andrew.mcmichael@ndm.ox.ac.uk

Abstract

The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.

PMID:
12001999
DOI:
10.1038/nri779
[Indexed for MEDLINE]

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