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Nat Rev Immunol. 2002 Apr;2(4):227-38.

Spinning molecular immunology into successful immunotherapy.

Author information

1
Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. dmpardol@jhmi.edu

Abstract

Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.

PMID:
12001994
DOI:
10.1038/nri774
[Indexed for MEDLINE]
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