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Nat Rev Cancer. 2002 Apr;2(4):301-10.

NF-kappaB in cancer: from innocent bystander to major culprit.

Author information

1
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093, USA. karinoffice@ucsd.edu

Abstract

Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.

PMID:
12001991
DOI:
10.1038/nrc780
[Indexed for MEDLINE]
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