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J Infect Dis. 2002 May 1;185(9):1369-72. Epub 2002 Apr 5.

Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats.

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Hand and Upper Limb Centre, Lawson Health Research Institute, Department of Surgery, University of Western Ontario, London, Canada.


Staphylococcus aureus is a common cause of community and hospital-acquired infections. Moreover, the clinical impact of S. aureus is on the rise because of the global increase in the incidence of multidrug-resistant strains and its growing prevalence as a major cause of surgical infections. As a result, there is a pressing need to identify new antistaphylococcal agents and preventative strategies that will help in the management of these types of infections. This report describes the successful use of a probiotic, Lactobacillus fermentum RC-14, and its secreted biosurfactant to inhibit surgical implant infections caused by S. aureus. L. fermentum RC-14 and its secreted biosurfactant both significantly inhibited S. aureus infection and bacteria adherence to surgical implants.

[Indexed for MEDLINE]

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