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Apoptosis. 2002 Jun;7(3):247-60.

Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

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Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.


Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.

[Indexed for MEDLINE]

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