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Vision Res. 2002 Apr;42(9):1081-7.

GABAc feedback pathway modulates the amplitude and kinetics of ERG b-wave in a mammalian retina in vivo.

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1
Department of Biological Sciences, Allergan Pharmaceuticals, RD-2C Allergan Inc., 2525 Dupont Drive, Irvine, CA 92612, USA. dong_james@allergan.com

Abstract

The electroretinogram b-wave is generally believed to reflect mainly light-induced activity of ON-center bipolar cells and Muller cells. Recently, there is increasing evidence that third-order retinal neurons can also contribute significantly to the b-wave. In a previous study (Vis. Res. 40 (2000) 579) we proposed that the GABAc feedback from amacrine cells to bipolar cells can affect both the amplitude and kinetics of the b-wave. Here we show that blocking this feedback has profound effects on b-wave amplitude and kinetics. These results demonstrate that feedback to bipolar cells is an important mechanism through which amacrine cells contribute to b-wave generation. Our results also provide functional evidence that the feedback may be involved in temporal processing in the mammalian retina.

PMID:
11997047
[Indexed for MEDLINE]
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