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Enferm Infecc Microbiol Clin. 2002 Apr;20(4):157-60.

[Evolution of the sensitivity of 235 strains of Helicobacter pylori from 1995 to 1998 and impact of antibiotic treatment].

[Article in Spanish]

Author information

1
Servicio de Microbiología, Hospital Mútua de Terrassa, Barcelona, Spain.

Abstract

BACKGROUND:

The aim of this study was to investigate the sensitivity of Helicobacter pylori to the antibiotics used in its eradication over a period of four years and to determine the influence of previous treatment on sensitivity.

MATERIAL AND METHODS:

During the period from 1995 to 1998 we determined the sensitivity of 235 consecutive Helicobacter pylori isolates to amoxicillin, metronidazole, clarythromycin and tetracycline by means of E-test methodology. The MIC values found were related with the prior use of eradicating treatment.

RESULTS:

The percentage of resistant strains were as follows: 23.5% to metronidazole, 12.9% to clarythromycin and 0.7% to tetracycline; none of the strains was resistant to amoxicillin. There were no significant changes in percentage of resistance to the drugs studied over the 4-year period. Resistance to metronidazole and clarythromycin was significantly higher (p 5 0.03 and p < 0.001 respectively) in strains isolated from patients who had received previous treatment.

CONCLUSIONS:

Monitorization of H. pylori sensitivity to the drugs used in its eradication is particularly important in patients who have undergone prior treatment.

PMID:
11996701
DOI:
10.1016/s0213-005x(02)72778-x
[Indexed for MEDLINE]

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