Send to

Choose Destination
See comment in PubMed Commons below
Acta Biochim Pol. 2001;48(4):1003-23.

Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems.

Author information

  • 1Institute of Biochemistry and Biophysics, Polish Academy of Sciences.


The stable inheritance of bacterial plasmids is achieved by a number of different mechanisms. Among them are resolution of plasmid oligomers into monomers, active plasmid partitioning into dividing cells and selective killing of plasmid-free segregants. A special focus is given to the last mechanism. It involves a stable toxin and an unstable antidote. The antidotes neutralize their cognate toxins or prevent their synthesis. The different decay rates of the toxins and the antidotes underlie molecular mechanisms of toxin activation in plasmid-free cells. By eliminating of plasmid-free cells from the population of plasmid-bearing ones the toxin-antidote couples therefore act as plasmid addiction systems.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Acta Biochemica Polonica, Inc.
    Loading ...
    Support Center