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Eur J Paediatr Neurol. 2002;6(2):115-9.

Congenital Guillain-Barré syndrome associated with maternal inflammatory bowel disease is responsive to intravenous immunoglobulin.

Author information

1
Department of Neurology, Columbia University College of Physicians and Surgeons, Neurological Institute, New York, NY 10032, USA. nsb4@columbia.edu

Abstract

A 34-week floppy preterm infant born to a mother with acute ulcerative colitis presented with a progressive reduction in spontaneous limb movements, severe generalized hypotonia, areflexia, autonomic dysfunction and respiratory failure. Electromyography revealed pronounced denervation activity and markedly slow nerve conduction velocity (3 m/s) with evidence of conduction block. These findings indicated demyelination with additional axonal features. The infant was diagnosed with congenital Guillain-Barré syndrome, was treated with intravenous immunoglobulin and showed clinical improvement within 48 hours of treatment. The relationship between inflammatory bowel syndrome and inflammatory demyelinating polyneuropathy is discussed.

PMID:
11995958
DOI:
10.1053/ejpn.2002.0557
[Indexed for MEDLINE]
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