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Nat Rev Neurosci. 2002 Mar;3(3):243-9.

The problem of functional localization in the human brain.

Author information

1
MRC Cognition and Brain Sciences Unit, Cambridge, UK. matthew.brett@mrc-cbu.cam.ac.uk

Abstract

Functional imaging gives us increasingly detailed information about the location of brain activity. To use this information, we need a clear conception of the meaning of location data. Here, we review methods for reporting location in functional imaging and discuss the problems that arise from the great variability in brain anatomy between individuals. These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function.

PMID:
11994756
DOI:
10.1038/nrn756
[Indexed for MEDLINE]

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