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Nat Rev Mol Cell Biol. 2002 Apr;3(4):246-55.

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol.

Author information

1
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.

PMID:
11994744
DOI:
10.1038/nrm780
[Indexed for MEDLINE]

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