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Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45.

v-Src's hold over actin and cell adhesions.

Author information

1
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. mframe@beatson..gla.ac.uk

Abstract

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

PMID:
11994743
DOI:
10.1038/nrm779
[Indexed for MEDLINE]

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