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Nat Rev Mol Cell Biol. 2002 Mar;3(3):195-205.

Messenger-RNA-binding proteins and the messages they carry.

Author information

1
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA. gdreyfuss@hhmi.upenn.edu

Abstract

From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.

PMID:
11994740
DOI:
10.1038/nrm760
[Indexed for MEDLINE]

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