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Nat Rev Mol Cell Biol. 2002 Mar;3(3):177-86.

Phosphotyrosine-binding domains in signal transduction.

Author information

1
Center for Cancer Research, E18-580, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. myaffe@mit.edu

Abstract

Protein phosphorylation provides molecular control of complex physiological events within cells. In many cases, phosphorylation on specific amino acids directly controls the assembly of multi-protein complexes by recruiting phospho-specific binding modules. Here, the function, structure, and cell biology of phosphotyrosine-binding domains is discussed.

PMID:
11994738
DOI:
10.1038/nrm759
[Indexed for MEDLINE]

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