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Nat Rev Mol Cell Biol. 2002 Mar;3(3):167-76.

Dynamic localization of proteins and DNA during a bacterial cell cycle.

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Genencor International Inc., 925 Page Mill Road, Palo Alto, California 94304-1013, USA.


A cellular differentiation programme that culminates in an asymmetric cell division is an integral part of the cell cycle in the bacterium Caulobacter crescentus. Recent work has uncovered mechanisms that ensure the execution of many events at different times during the cell cycle and at specific places in the cell. Surprisingly, in this one-micron bacterial cell, the dynamic spatial disposition of regulatory proteins, structural proteins and specific regions of the chromosome are important components of both cell-cycle progression and the generation of daughter cells with different cell fates.

[Indexed for MEDLINE]

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