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Bioorg Med Chem Lett. 2002 May 20;12(10):1405-11.

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.

Author information

1
Department of Medicinal Chemistry, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Herts, UK.

Abstract

The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

PMID:
11992787
DOI:
10.1016/s0960-894x(02)00160-9
[Indexed for MEDLINE]

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