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Bioorg Med Chem Lett. 2002 May 20;12(10):1399-404.

Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives.

Author information

1
Department of Medicinal Chemistry, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Herts, UK.

Abstract

Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.

PMID:
11992786
DOI:
10.1016/s0960-894x(02)00159-2
[Indexed for MEDLINE]

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