Send to

Choose Destination
Am J Hypertens. 2002 Apr;15(4 Pt 1):321-5.

Reduction in arterial stiffness with angiotensin II antagonist is comparable with and additive to ACE inhibition.

Author information

Department of Pharmacology and Therapeutics, Trinity Centre and Hypertension Clinic. St. James's Hospital, Dublin. Ireland.


We measured the effects of angiotensin II blockade on arterial stiffness, augmentation index (AI%), pulse wave velocity (PWV), and blood pressure (BP) in 12 hypertensive patients (mean 49 +/- 11 years) in a 4-week, randomized, cross-over study comparing valsartan 160 mg/day with captopril 100 mg/day, with a 2-week washout period. Subsequently both therapies were combined. Reductions in PWV and AI% remained significant when corrected for BP. Combined therapy reduced PWV and AI% (P < .05) more than monotherapy, even when corrected for BP. The study shows that angiotensin receptor antagonists reduce arterial stiffness in hypertension comparable with and possibly additive to angiotensin converting enzyme inhibition.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center