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Nat Rev Cancer. 2002 Mar;2(3):231-8. doi: 10.1038/nrc748.

History of haematopoietic stem-cell transplantation.

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1
Transplantation Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

Abstract

After fifty years of investigations into the use of pluripotent haematopoietic stem-cell transplantation for cancer therapy, this procedure has progressed from one that was thought to be plagued with insurmountable complications to a standard treatment for many haematological malignancies. How have these hurdles been overcome, and how can the therapy be expanded to include patients who are too old or medically infirm to tolerate conventional transplant approaches?

PMID:
11990860
DOI:
10.1038/nrc748
[Indexed for MEDLINE]
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