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Nat Rev Cancer. 2002 Mar;2(3):188-200.

DNA and its associated processes as targets for cancer therapy.

Author information

1
College of Pharmacy, The University of Arizona, Tucson 85721, USA. hurley@pharmacy.arizona.edu

Abstract

DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

PMID:
11990855
DOI:
10.1038/nrc749
[Indexed for MEDLINE]

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