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Nat Rev Cancer. 2002 Mar;2(3):161-74.

New functions for the matrix metalloproteinases in cancer progression.

Author information

1
Department of Anatomy, University of California at San Francisco, 94143-0452, USA. egeblad@itsa.ucsf.edu

Abstract

Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results. We now know, however, that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer. With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic?

PMID:
11990853
DOI:
10.1038/nrc745
[Indexed for MEDLINE]

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