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Ann Trop Med Parasitol. 2002 Jan;96(1):19-23.

Immunochromatographic strip-test detection of anti-K39 antibody in Indian visceral leishmaniasis.

Author information

1
Kala-Azar Medical Research Center, Banaras Hindu University, Institute of Medical Sciences, Varanasi, India. shyam_vns@satyam.net.in

Abstract

Stored sera from 429 Indian subjects were assayed to extend the analysis of the accuracy of immunochromatographic strip-test detection of anti-K39 antibody in the non-invasive diagnosis of visceral leishmaniasis (VL). All 225 samples from patients with proven Leishmania infection tested positive [estimated sensitivity = 100%; 95% confidence interval (CI)=98%-100%]. Sera from 99 of the 100 symptomatic patients with other diseases were non-reactive (estimated specificity = 99%; CI = 94%-100%). However, samples from 13 of the 104 apparently healthy controls showed positive strip-test results (estimated specificity = 88%; CI = 79%-93%), yielding an overall specificity of 93% (190/204; CI = 88%-96%). If applied in a practical clinical setting (on symptomatic patients in whom active VL is suspected and other common infections have been excluded), strip testing of serum for anti-K39 antibody should be both sensitive and specific for diagnosing VL in India.

PMID:
11989529
DOI:
10.1179/000349802125000466
[Indexed for MEDLINE]

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