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Nat Rev Mol Cell Biol. 2002 May;3(5):382-9.

Opinion: peroxisomal-protein import: is it really that complex?

Author information

1
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sgould@jhmi.edu

Abstract

Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.

PMID:
11988772
DOI:
10.1038/nrm807
[Indexed for MEDLINE]

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