Format

Send to

Choose Destination
Nat Rev Genet. 2002 May;3(5):380-90.

Genealogical trees, coalescent theory and the analysis of genetic polymorphisms.

Author information

1
Program in Molecular and Computational Biology, University of Southern California, 835 West 37th Street, SHS172, Los Angeles, California 90089-1340, USA.

Abstract

Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

PMID:
11988763
DOI:
10.1038/nrg795
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center