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Nat Rev Genet. 2002 May;3(5):370-9.

Alu repeats and human genomic diversity.

Author information

1
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA. mbatzer@lsu.edu

Abstract

During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages. Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression. Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

PMID:
11988762
DOI:
10.1038/nrg798
[Indexed for MEDLINE]

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