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Annu Rev Biophys Biomol Struct. 2002;31:361-92. Epub 2001 Oct 25.

Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions.

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Department of Biochemistry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7760, San Antonio, TX 78229-3900, USA.


Chromatin fibers are dynamic macromolecular assemblages that are intimately involved in nuclear function. This review focuses on recent advances centered on the molecular mechanisms and determinants of chromatin fiber dynamics in solution. Major points of emphasis are the functions of the core histone tail domains, linker histones, and a new class of proteins that assemble supramolecular chromatin structures. The discussion of important structural issues is set against a background of possible functional significance.

[Indexed for MEDLINE]

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