Format

Send to

Choose Destination
Lancet. 2002 Apr 27;359(9316):1486-8.

Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.

Author information

1
Department of Perinatology, University Hospital, Nantes, France.

Abstract

We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation. Echocardiography showed severely decreased pulmonary blood flow. Hypoxaemia resolved quickly on inhaled nitric oxide therapy. We suggest that investigators involved in similar trials pay close attention to pulmonary pressure if hypoxaemia occurs after prophylactic administration of ibuprofen.

PMID:
11988250
DOI:
10.1016/S0140-6736(02)08424-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center