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Interaction of ACE inhibitors and AT(1)-receptor blockers on maximum blood pressure response in spontaneous hypertensive rats.

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Department of Physiology, University of Melbourne, Parkville, Vic, Australia.


This study in spontaneous hypertensive rats (SHR) was designed to determine whether a greater fall in blood pressure (BP) could be achieved with the combination of an angiotensin-converting enzyme inhibitor (ACE-I) and an AT(1)-receptor blocking drug than with higher doses of either drug alone. The peak effect of captopril occurred 3 4 hours post-dose and a plateau response was achieved with 10 mg/kg. The peak effect of losartan occurred 7 8 hours post-dose and a plateau response was achieved with 10 mg/kg. Increasing the dose of either drug caused no greater fall in BP, but increased the duration of the effect. Captopril, 10 mg/kg, administered with losartan 10 mg/kg caused a greater fall in BP than captopril or losartan, 20 mg/kg. This was present after acute doses or after one week of daily therapy. The combination of ACE-I and AT(1)-blocking drugs is more effective than either therapy alone and may be a useful combination to manage hypertension and/or cardiac failure.

[Indexed for MEDLINE]

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